Plant Fibres, Starch and Drug Testing
Plant cells have a cellulose cell wall, middle lamella (calcium pectate), plasmodesmata, amyloplasts (starch storage), chloroplasts and a large vacuole with tonoplast. Sclerenchyma fibres are dead, elongated cells with thick lignified walls: high tensile strength, used for rope, textiles and composites (more sustainable than oil-based plastics). Measure tensile strength by hanging masses until a fibre breaks. Mineral ions: nitrates (proteins, DNA), calcium (middle lamella), magnesium (chlorophyll). Plants make antimicrobial substances (e.g. garlic, tea tree); test with discs on bacterial lawns. Drug testing: William Withering's foxglove trials (digitalis, 1785) were early dose–response studies. Modern trials: preclinical (cells, animals) → phase 1 (small healthy group, safety) → phase 2 (patients, effectiveness and dose) → phase 3 (large, randomised, double-blind, placebo-controlled).
Learning objectives
- Describe plant cell ultrastructure.
- Relate fibre structure to strength and uses.
- Describe measuring tensile strength.
- Describe drug testing past and present.
Why is a double-blind trial better than one where doctors know who gets the drug?
Core idea
For thousands of years people have made rope, cloth and paper from plant fibres. Their strength comes from cellulose and lignin.
Plant cell structures give strength and storage useful to humans; plants also provide medicines, tested in careful staged trials.
Each phase bigger than the last.
A fibre breaks with 0.60 kg hung on it.
- Goal
- Force.
- Strategy
- F = mg.
- Weight.
- Evaluate.
Summary
- Cellulose, lignin, middle lamella.
- Tensile strength practical.
- Trial phases.
- Sclerenchyma
- Dead, lignified supporting tissue.
- Double-blind
- Neither patient nor doctor knows who receives the drug.
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